Taken together, findings from neuroi

Taken together, findings from neuroimaging studies suggest that the abnormal maturation of the overlapping frontostriatal and mesolimbic circuits supporting self-regulation and reward-based learning may contribute to the development and maintenance of BN. fMRI findings suggest that the failure of women with BN to engage frontostriatal systems appropriately contributes to their impairments in self-regulatory control, and that functional disturbances in frontostriatal regions arise early in adolescence. Anatomical findings suggest that reductions on the surface of inferior frontal cortices may contribute to these functional deficits in selfregulation that persist over the course of this illness.